Current Issue : July - September Volume : 2020 Issue Number : 3 Articles : 5 Articles
The rhizome of Anemarrhena asphodeloides Bunge, used in Traditional Chinese Medicine as\na brain function-improving herb, is a promising source of neuroprotective substances. The aim of\nthis study was to evaluate the protective action of xanthones from A. asphodeloides rhizomes on the\nPC12 cell line exposed to the neurotoxic agent-3-nitropropionic acid (3-NP). The xanthone-enriched\nfraction of the ethanolic extract of A. asphodeloides (abbreviated from now on as XF, for the Xanthone\nFraction), rich in polyphenolic xanthone glycosides, in concentrations from 5 to 100...............
Rhamnus prinoides Lâ??Herit (R. prinoides) has long been widely consumed as folk medicine in\nKenya and other Africa countries. Previous studies indicated that polyphenols were abundant in\ngenus Rhamnus and exhibited outstanding antioxidant and anti-inflammatory activities. However,\nthere are very few studies on such pharmacological activities and the polyphenol profile of this\nplant up to now. In the present study, the antioxidant activities of the crude R. prinoides extracts\n(CRE) and the semi-purified R. prinoides extracts (SPRE) of polyphenol enriched fractions were\nevaluated to show the strong radical scavenging effects against 1,1-diphenyl-2- picrylhydrazyl radical\n2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH)....................
In the current study, to combat insecticide resistance, we explored larvicidal, ovicidal,\nsynergistic, and repellent activities of Sophora alopecuroides extract and its dominant constituents\nagainst Aedes albopictus. The results of the toxicity bioassays demonstrated that the extract of\nS. alopecuroides exerted significant larvicidal activity (16.66-86.66%) against the third-instar larvae\nof Ae. albopictus at dierent concentrations.......................
Neuroinflammation is involved in various neurological diseases. Activated microglia\nsecrete many pro-inflammatory factors and induce neuronal cell death. Thus, the inhibition of\nexcessive proinflammatory activity of microglia leads to a therapeutic effect that alleviates the\nprogression of neuronal degeneration. In this study, we investigated the effect of Croton tiglium (C.\ntiglium) Linn. extract (CTE) on the production of pro- and anti-inflammatory mediators in microglia\nand astrocytes via RT-PCR, Western blot, and nitric oxide assay. Neurotoxicity was measured by\ncell viability assay and GFP image analysis. Phagocytosis of microglia was measured using\nfluorescent zymosan particles. CTE significantly inhibited the production of neurotoxic\ninflammatory factors, including nitric oxide and tumor necrosis factor.........................
The prevalence of obesity is increasing globally. Despite the availability of a variety of\nanti-obesogenic drugs, including therapies under clinical development, these treatments are often\nindicated for patients with severe obesity, making them unsuitable for patients with mild obesity\nor for preventative use. In Thailand, traditional remedies employing medicinal plants are widely\nused to maintain health and treat disease. These treatments are generally inexpensive and readily\navailable at markets, making them good treatment options for preventing obesity. To evaluate the\nanti-obesogenic potential of Thai medicinal plants, we employed three in vitro methods: pancreatic\nlipase inhibition, lipolysis enhancement, and lipid accumulation reduction assays. Among 70 Thai\nmedicinal plants, Eurycoma longifolia Jack, Tiliacora triandra Diels, and Acacia concinna (Willd.) DC.\nwere selected as the most favorable candidates because they exhibited anti-obesogenic activity in all\nthree assays. These medicinal plants are expected to have effcient anti-obesogenic effects, making\nthem promising candidates for further study....
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